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Description

These shifts are compounded by impaired antioxidant defenses, including downregulation of GPX4 and system Xc - which diminish glutathione synthesis and the capacity to neutralize lipid hydroperoxides

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Quality by design based formulation of xanthohumol loaded solid lipid nanoparticles with improved bioavailability and anticancer effect against PC-3 cells

J Biol Chem 268 : 1788317888

Future opportunities include hybrid nanoplatforms that integrate redox responsiveness with imaging and enhanced safety, as well as the use of patient-specific GSH/GSSG profiles to guide individualized therapy